Publications

Peer-reviewed publications reflecting NBIIC-HI’s research focus in mechanism-driven translational medicine, immunoregulation, microenvironment modulation, and targeted therapeutic innovation.

2026

NGR-modified cancer-associated fibroblast-derived exosomes deliver resveratrol to inhibit CXCR2/NF-κB signaling and reverse immune suppression in liver cancer.

International Immunopharmacology.

Research Area: Extracellular vesicles; targeted delivery; immunoregulation; liver cancer.

PAARH suppresses Kupffer cell phagocytosis to promote tumor liver metastasis by upregulating CD47.

Cancer Cell International.

Research Area: Tumor microenvironment; Kupffer cells; CD47; liver metastasis.

Integrative Genomic Analysis Reveals Insulin Resistance as a Key Mediator in the Causal Link Between Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Hypertension.

JMA Journal.

Research Area: MASH; insulin resistance; hypertension; integrative genomics; causal mediation.

Engineering Protease-Resistant Peptides via Non-canonical Amino Acids: Design Strategies and Biosynthetic Advances.

Bioengineering-Basel.

Research Area: Protease-resistant peptides; non-canonical amino acids; peptide engineering; peptide therapeutics; synthetic biology; biosynthetic engineering.

Humanized porcine kidneys display pre-transplant injury-associated proximal tubular states.

Medicine Advances.

Research Area: Xenotransplantation; Kidney injury; Single-cell RNA sequencing; Renal biology.

Selected Earlier Publications (21)

Selected representative publications published before the establishment of NBIIC-HI by researchers currently associated with the Institute and selected core collaborators are presented to provide academic context and reflect the scholarly foundations supporting the Institute's development.

Leveraging Machine Learning for Drug Repurposing in Rheumatoid Arthritis.

Drug Discovery Today. 2025. View Article

Research Areas: Rheumatoid arthritis; machine learning; drug repurposing; artificial intelligence; translational drug discovery.

A Novel pH-Sensitive Nanoparticle Encapsulating Anti-PD-1 Antibody and MDK-siRNA Overcomes Immune Checkpoint Blockade Resistance in HCC by Reshaping the Immunosuppressive Tumor Microenvironment.

Journal of Experimental & Clinical Cancer Research. 2025. View Article

Research Areas: Hepatocellular carcinoma; immune checkpoint blockade; pH-sensitive nanoparticles; siRNA delivery; immunosuppressive tumor microenvironment.

A novel exosome-based multifunctional nanocomposite platform driven by photothermal-controlled release system for repair of skin injury.

Journal of Controlled Release. 2024. View Article

Research Areas: Engineered exosomes; controlled drug delivery; MXene-based biomaterials; photothermal therapy; regenerative medicine; wound repair.

Immunogenic Material Vaccine for Cancer Immunotherapy by Structure-Dependent Immune Cell Trafficking and Modulation.

Advanced Materials. 2024. View Article

Research Areas: Cancer immunotherapy; immunogenic biomaterials; immune cell trafficking; immune modulation.

Preoperative Neoadjuvant Targeted Therapy Remodels Intratumoral Heterogeneity of Clear-Cell Renal Cell Carcinoma and Ferroptosis Inhibition Induces Resistance Progression.

Cancer Letters. 2024. View Article

Research Areas: Clear-cell renal cell carcinoma; neoadjuvant targeted therapy; tumor heterogeneity; ferroptosis; therapeutic resistance.

Transcatheter Arterial Chemoembolisation Combined with Lenvatinib and Cabozantinib in the Treatment of Advanced Hepatocellular Carcinoma.

International Immunopharmacology. 2024. View Article

Research Areas: Hepatocellular carcinoma; transcatheter arterial chemoembolisation; targeted therapy; treatment response; clinical prognosis.

Drugs Causing Prostate-Specific Antigen Changes: The Food and Drug Administration Adverse Event Reporting System Combined with Mendelian Randomization Analysis.

Expert Opinion on Drug Safety. 2024. View Article

Research Areas: Prostate-specific antigen; pharmacovigilance; adverse drug reactions; Mendelian randomization; real-world data.

Drugs Associated with Urinary Retention Adverse Reactions: A Joint Analysis of the FDA Adverse Event Reporting System and Mendelian Randomization.

Urology. 2024. View Article

Research Areas: Urinary retention; drug safety; pharmacovigilance; Mendelian randomization; urological adverse events.

Fe-Coordinated Carbon Dots with Single-Atom Nanozyme Catalytic Activity for Synergistic Catalytic/Chemo-Therapy in Breast Cancer

International Journal of Biological Macromolecules. 2024. View Article

Research Areas: Breast cancer; carbon dots; single-atom nanozymes; catalytic therapy; chemotherapy; nanomedicine.

Alteration of Gut Microbiota in Individuals at High-Risk for Rheumatoid Arthritis Associated With Disturbed Metabolome and the Initiation of Arthritis Through the Triggering of Mucosal Immunity Imbalance

Arthritis & Rheumatology. 2023. View Article

Research Areas: Rheumatoid arthritis; gut microbiome; metabolomics; mucosal immunity; Th17 cells; fecal microbiota transplantation.

Mechanism of congenital lymphocytes and intestinal immunity regulated by gut microbial metabolites via metabolite-sensing receptor Ffar2.

Cancer Insight. 2023. View Article

Research Area: Microbiome–immune regulation; intestinal inflammation; metabolite-sensing receptors; Ffar2 signaling; translational immunology.

Targeting NEDD8-Activating Enzyme for Cancer Therapy: Developments, Clinical Trials, Challenges and Future Research Directions.

Journal of Hematology & Oncology. 2023. View Article

Research Areas: NEDDylation; NEDD8-activating enzyme; targeted cancer therapy; clinical translation; drug development.

Long Noncoding RNA FGD5-AS1 Alleviates Childhood IgA Nephropathy by Targeting PTEN-Mediated JNK/c-Jun Signaling via miR-196b-5p.

Experimental Cell Research. 2023. View Article

Research Areas: Pediatric IgA nephropathy; long noncoding RNA; miR-196b-5p; PTEN; JNK/c-Jun signaling; molecular therapeutics.

circCELF1 Inhibits Myocardial Fibrosis by Regulating the Expression of DKK2 Through FTO/m6A and miR-636

Journal of Cardiovascular Translational Research. 2022. View Article

Research Areas: Myocardial fibrosis; circular RNA; m6A modification; FTO; miR-636; DKK2; cardiovascular translational research.

Gut Microbiome and Metabolites in Systemic Lupus Erythematosus: Link, Mechanisms and Intervention

Frontiers in Immunology. 2021. View Article

Research Areas: Systemic lupus erythematosus; gut microbiome; metabolites; immune dysregulation; biomarkers; microbiota-based intervention.

Circulating Regulatory T Cells Were Absolutely Decreased in Dermatomyositis/Polymyositis patients and Restored by Low-Dose IL-2.

Annals of the Rheumatic Diseases. 2021. View Article

Research Areas: Dermatomyositis; polymyositis; regulatory T cells; low-dose IL-2; immune restoration.

SDHB Suppresses the Tumorigenesis and Development of Clear-Cell Renal Cell Carcinoma by Inhibiting Glycolysis.

Frontiers in Oncology. 2021. View Article

Research Areas: Clear-cell renal cell carcinoma; SDHB; glycolysis; tumor metabolism; therapeutic targets.

Discovery of Novel Tertiary Amide Derivatives as NEDDylation Pathway Activators to Inhibit Tumor Progression In Vitro and In Vivo.

European Journal of Medicinal Chemistry. 2020. View Article

Research Areas: Medicinal chemistry; NEDDylation pathway; small-molecule discovery; anticancer agents; in vitro and in vivo validation.

Inhibition of Cytosolic Phospholipase A2 Alpha Increases Chemosensitivity in Cervical Carcinoma Through Suppressing β-Catenin Signaling.

Cancer Biology & Therapy. 2019. View Article

Research Areas: Cervical cancer; chemotherapy sensitivity; cytosolic phospholipase A2α; β-catenin signaling; therapeutic resistance.

Cyclin D1-Mediated microRNA Expression Signature Predicts Breast Cancer Outcome.

Theranostics. 2018. View Article

Research Areas: Breast cancer; Cyclin D1; microRNA signatures; prognostic biomarkers; precision oncology.

Disruption of the Golgi Protein Otg1 Gene Causes Defective Hormone Secretion and Aberrant Glucose Homeostasis in Mice.

Cell & Bioscience. 2016. View Article

Research Areas: Golgi biology; hormone secretion; glucose homeostasis; metabolic regulation; mouse models.

Norman Bethune International Institute of Canada