Advancing Promising Discoveries Toward
Validation, Collaboration, and Application
Technology translation is the structured process of advancing promising scientific discoveries, technical capabilities, therapeutic concepts, research tools, and healthcare innovations toward validation and potential application.
NBIIC-HI supports this process by helping project teams assess development needs, strengthen translation frameworks, identify suitable collaborators, and connect with appropriate academic, clinical, technical, institutional, and innovation pathways.
NBIIC-HI does not view technology translation as a single-step process. Translation may involve multiple stages, including scientific validation, technical optimization, clinical relevance assessment, intellectual property considerations, partner identification, regulatory planning, and development of an appropriate application pathway.
The pathway for each project is determined by its scientific maturity, intended use, institutional context, available evidence, and development objectives.
Reviewing the scientific foundation, development stage, evidence base, unmet need, and potential application of a proposed technology or innovation.
Identifying appropriate technical, biological, preclinical, computational, clinical, or real-world validation requirements.
Connecting project teams with relevant laboratories, hospitals, research institutions, technical platforms, manufacturers, or innovation organizations.
Structuring development stages, milestones, responsibilities, required resources, and potential decision points.
Supporting preliminary consideration of intellectual property and potential translation pathways while referring legal, financial, licensing, and regulatory matters to appropriately qualified professionals and institutions.
Facilitating cross-border collaboration involving research validation, technology development, institutional cooperation, application assessment, or implementation opportunities.
Depending on the project, translation may lead to further research, collaborative validation, licensing, co-development, product development, clinical evaluation, or, where appropriate, the development of a dedicated innovation or venture initiative.
Selected intellectual property and translational research activities developed before the establishment of NBIIC-HI by researchers currently associated with the Institute are presented to provide historical context and reflect scientific foundations relevant to the Institute's interests in microbial biotechnology, natural-product biosynthesis, process optimization, and research-to-application pathways.
Published Chinese Patent Application: CN101260418A
Research Areas: Microbial fermentation; natural-product biosynthesis; bioprocess optimization; antimicrobial compounds.
Granted Chinese Invention Patent: ZL202210704817.1
Research Areas: NEDDylation signaling; molecular screening platforms; targeted drug discovery; small-molecule inhibitors.
Granted Chinese Invention Patent: ZL202211622932.0
Research Areas: Epigenetic drug discovery; LSD1 inhibition; virtual screening; acute myeloid leukemia.
Granted Chinese Invention Patent: ZL201711406285.9
Research Areas: Tubulin-targeted therapeutics; medicinal chemistry; click chemistry; anticancer lead discovery.
Published Chinese Patent Application: CN120365274A
Research Areas: Autoimmune disease; B-cell differentiation; autoantibody regulation; small-molecule drug discovery; immunomodulatory therapeutics.
Granted Chinese Invention Patent: CN118453870B
Research Areas: AKT1-targeted therapy; pigmented villonodular synovitis; synovial fibroblast biology; mechanism-driven drug discovery.
Published Chinese Patent Application: CN115414387A
Research Areas: Pulmonary fibrosis; microvesicle-based therapy; inhaled drug delivery; translational bioengineering.
Granted Chinese Invention Patent: CN116539892B
Research Areas: Clinical proteomics; protein biomarker discovery; clear cell renal cell carcinoma; diagnostic model development; early cancer detection.
Published Chinese Patent Application: CN116103404A
Research Areas: Single-cell transcriptomics; molecular tumor classification; tumor microenvironment; prognostic assessment; precision oncology.
Published Chinese Patent Application: CN122104600A
Research Areas: Metastatic cancer models; renal cancer biology; dual-reporter cell lines; in vivo imaging; preclinical drug screening.
Published Chinese Patent Application: CN115369156A
Research Areas: Gut microbiome; autoimmune diseases; enterotype scoring; treatment-response prediction; precision medicine.
Published Chinese Patent Application: CN116144761A
Research Areas: Rheumatoid arthritis; immune-microenvironment profiling; gene-expression analysis; diagnostic classification; personalized treatment.
Published Chinese Patent Application: CN118557576A
Research Areas: Drug repurposing; rheumatoid arthritis; MAPK signaling; Treg-mediated immunoregulation; translational therapeutics.
Published Chinese Patent Application: CN116421613A
Research Areas: Engineered extracellular vesicles; miRNA therapeutics; neuroinflammation; neurodegenerative diseases; regenerative medicine.
Granted Chinese Invention Patent: CN107050624B
Research Areas: Benign prostatic hyperplasia; minimally invasive urology; balloon-catheter technology; procedural standardization; medical-device translation.
Published Chinese Patent Application: CN120459504A
Research Areas: Interventional medical devices; balloon-expansion technology; precision control; procedural safety; translational urology.
NBIIC-HI supports responsible technology translation and respects the scientific, ethical, legal, financial, regulatory, intellectual property, and administrative responsibilities of participating institutions.
Where specialized approval or professional advice is required, projects should proceed through appropriately authorized institutions and qualified legal, regulatory, clinical, financial, or technical professionals.
We welcome enquiries regarding promising technologies, therapeutic concepts, research tools, platforms, and healthcare innovations at different stages of development.
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